chromogranin

CHROMOGRANIN A, Mouse MAb anti-human

Catalog number:-MM-1013-01    0.5  ml         Concentrated          IgG1    0.1 mg/ml

                              MM-1013-02    1.0 ml          Concentrated           IgG1    0.1 mg/ml  

                              MM-1013-04    7.0 ml          Prediluted for IHC  IgG1  ~2µg/ml

Buffer: The concentrated antibodies are supplied in PBS with 1% BSA,  0.05% azide, pH 7.4. The Prediluted antibody is supplied in our Universal antibody dilution buffer (AR-6526) green in color.

Description: :. Chromogranin A (a 439 aa protein MW about 70 KDa) or parathyroid secretory protein 1 (gene name CHGA) is a member of the Chromogranin/secretogranin (granins) family of neuroendocrine secretory proteins, i.e. it is located in secretory vesicles of neurons and endocrine cells. Examples of cells producing Chromogranin A are chromaffin cells of the adrenal medulla, enterochromaffin-like cells and beta cells of the pancreas. It is a good marker for characinoid tumors, pheochromocytoma, paraganglomas and other endocrine tumors.

Intended Use: Immunohistochemistry (IHC) and Immunocytchemistry (ICC)

Storage: 2-8°C

Clone: LK2H10                                         Isotype: IgG1,/ κ

Epitope: Not determined

Immunogen:.Human pheochromocytoma.

Species reactivity: Human, monkey, porcine, rabbit, rat, others not tested.

Cellular Localization: Cytoplasmic

Recommended positive control: Human pancreas

Application: IHC, ICC (frozen or formalin–fixed paraffin-embedded (FFPE) tissue sections, cell smears.

For IHC dilute conc. antibodies 1:50-1:100, use streptavidin~biotin system or polymer system, incubate 30 minutes at room temperature.

Prediluted antibody is ready to be used for IHC.

 The optimum dilution should be determined by the individual lab.

General References: General References:

1.      Lloyd, RV et.al. Science 222: 628-630, 1983

2.      Wirnsberger, G H Am. J Surg. Pathol. 16: 49-57, 1992

3.      Anderson, CL et al. Mol. Cell Proteomics 6: 1039-1048, 2007

4.      Birkenkamp-Dent QUOTE  

Limitation and warranty: Our warranty is limited to the actual price paid for the product. We are not liable for any property damage, personnel injury, time, effort or economic loss due to our product.

MSDS: This product contains 0.05 % sodium azide as a preservative, appropriate care should be taken in handling. National Institute of Occupational Safety and Health has warning that sodium azide can react with lead, copper, brass or solder in the plumbing system and forms  hydrazoic acid  in acidic condition. Discard with copious amount of water. Avoid skin and eye contact with all laboratory products. Use appropriate lab. gear, lab coat , gloves and  safety glasses. Do not ingest any lab. products. This product is not approved for administration in human or animals.

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Last modified: 05/13/09