LC-SPDP

Succinimidyl 6-(3-[2-pyridyldithio]-propionamido)hexanoate (LC-SPDP) CAS # n/a

Succinimidyl 6-(3-[2-pyridyldithio]-propionamido)hexanoate (LC-SPDP) is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional crosslinker. The "long chain" LC-SPDP has a 15.7 angstrom spacer arm, compared to the shorter 6.8 angstrom spacer arm version of SPDP. Often, due to steric hindrances, it is desirable to empirically test which of the two versions will work best in your specific application.

LC-SPDP's reactive moites consist of an N-hydroxysuccinimide (NHS) ester that reacts with primary amines, as found in lysine side chains. While on the other end of the LC-SPDP molecule pyridinyldisulfide reacts with sulhydryls to yield a reversible disulfide bond.

Molecular Weight: 425.5

Spacer Length: 15.7Å

LC-SPDP

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Copyright © 2009 GENTAUR BVBA
Last modified: 05/13/09